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T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC

T-cell activation results from productive T-cell receptor (TCR) engagement by a cognate peptide–MHC (pMHC) complex on the antigen presenting cell (APC) surface, a process leading to the polarization of the T-cell secretory machinery toward the APC interface. We have previously shown that the half-li...

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Autors principals: Carreño, Leandro J., Riquelme, Erick M., González, Pablo A., Espagnolle, Nicolas, Riedel, Claudia A., Valitutti, Salvatore, Kalergis, Alexis M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806700/
https://ncbi.nlm.nih.gov/pubmed/20075022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911258107
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