A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells

Both p53 and the Wnt signaling pathway play important roles in regulating the differentiation of mouse embryonic stem cells (mESCs). However, it is not known whether they directly and/or functionally crosstalk in mESCs. Here we report a surprising antidifferentiation function of p53 in mESCs through...

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Bibliografiska uppgifter
Huvudupphovsmän: Lee, Kyoung-Hwa, Li, Mangmang, Michalowski, Aleksandra M., Zhang, Xinyue, Liao, Hongling, Chen, Lingyi, Xu, Yang, Wu, Xiaolin, Huang, Jing
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2009
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806696/
https://ncbi.nlm.nih.gov/pubmed/20018659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909734107
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