A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells

Both p53 and the Wnt signaling pathway play important roles in regulating the differentiation of mouse embryonic stem cells (mESCs). However, it is not known whether they directly and/or functionally crosstalk in mESCs. Here we report a surprising antidifferentiation function of p53 in mESCs through...

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Bibliografiske detaljer
Main Authors: Lee, Kyoung-Hwa, Li, Mangmang, Michalowski, Aleksandra M., Zhang, Xinyue, Liao, Hongling, Chen, Lingyi, Xu, Yang, Wu, Xiaolin, Huang, Jing
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806696/
https://ncbi.nlm.nih.gov/pubmed/20018659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909734107
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