An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis

Plasmalemmal phosphatidylinositol (PI) 4,5-bisphosphate (PI4,5P(2)) synthesized by PI 4-phosphate (PI4P) 5-kinase (PIP5K) is key to the polymerization of actin that drives chemotaxis and phagocytosis. We investigated the means whereby PIP5K is targeted to the membrane and its fate during phagosome f...

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Bibliografiske detaljer
Main Authors: Fairn, Gregory D., Ogata, Koji, Botelho, Roberto J., Stahl, Philip D., Anderson, Richard A., De Camilli, Pietro, Meyer, Tobias, Wodak, Shoshana, Grinstein, Sergio
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2009
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806594/
https://ncbi.nlm.nih.gov/pubmed/19951917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909025
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