An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis

Plasmalemmal phosphatidylinositol (PI) 4,5-bisphosphate (PI4,5P(2)) synthesized by PI 4-phosphate (PI4P) 5-kinase (PIP5K) is key to the polymerization of actin that drives chemotaxis and phagocytosis. We investigated the means whereby PIP5K is targeted to the membrane and its fate during phagosome f...

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Détails bibliographiques
Auteurs principaux: Fairn, Gregory D., Ogata, Koji, Botelho, Roberto J., Stahl, Philip D., Anderson, Richard A., De Camilli, Pietro, Meyer, Tobias, Wodak, Shoshana, Grinstein, Sergio
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2009
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806594/
https://ncbi.nlm.nih.gov/pubmed/19951917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909025
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