An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis

Plasmalemmal phosphatidylinositol (PI) 4,5-bisphosphate (PI4,5P(2)) synthesized by PI 4-phosphate (PI4P) 5-kinase (PIP5K) is key to the polymerization of actin that drives chemotaxis and phagocytosis. We investigated the means whereby PIP5K is targeted to the membrane and its fate during phagosome f...

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Hlavní autoři: Fairn, Gregory D., Ogata, Koji, Botelho, Roberto J., Stahl, Philip D., Anderson, Richard A., De Camilli, Pietro, Meyer, Tobias, Wodak, Shoshana, Grinstein, Sergio
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2009
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806594/
https://ncbi.nlm.nih.gov/pubmed/19951917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909025
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