Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

Proline-rich tyrosine kinase 2 (PYK2) can be activated by angiotensin II (Ang II) and reactive oxygen species. We report that in endothelial cells, Ang II enhances the tyrosine phosphorylation of endothelial NO synthase (eNOS) in an AT(1)-, H(2)O(2)-, and PYK2-dependent manner. Low concentrations (1...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Loot, Annemarieke E., Schreiber, Judith G., Fisslthaler, Beate, Fleming, Ingrid
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2009
Gaiak:
Brief Definitive Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806451/
https://ncbi.nlm.nih.gov/pubmed/19934023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090449
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