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Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase
Proline-rich tyrosine kinase 2 (PYK2) can be activated by angiotensin II (Ang II) and reactive oxygen species. We report that in endothelial cells, Ang II enhances the tyrosine phosphorylation of endothelial NO synthase (eNOS) in an AT(1)-, H(2)O(2)-, and PYK2-dependent manner. Low concentrations (1...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806451/ https://ncbi.nlm.nih.gov/pubmed/19934023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090449 |
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