Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

Proline-rich tyrosine kinase 2 (PYK2) can be activated by angiotensin II (Ang II) and reactive oxygen species. We report that in endothelial cells, Ang II enhances the tyrosine phosphorylation of endothelial NO synthase (eNOS) in an AT(1)-, H(2)O(2)-, and PYK2-dependent manner. Low concentrations (1...

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Detalhes bibliográficos
Main Authors: Loot, Annemarieke E., Schreiber, Judith G., Fisslthaler, Beate, Fleming, Ingrid
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806451/
https://ncbi.nlm.nih.gov/pubmed/19934023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090449
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