Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

Peroral infection with Toxoplasma gondii leads to the development of small intestinal inflammation dependent on Th1 cytokines. The role of Th17 cells in ileitis is unknown. We report interleukin (IL)-23–mediated gelatinase A (matrixmetalloproteinase [MMP]-2) up-regulation in the ileum of infected mi...

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Main Authors: Muñoz, Melba, Heimesaat, Markus M., Danker, Kerstin, Struck, Daniela, Lohmann, Uwe, Plickert, Rita, Bereswill, Stefan, Fischer, André, Dunay, Ildikò Rita, Wolk, Kerstin, Loddenkemper, Christoph, Krell, Hans-Willi, Libert, Claude, Lund, Leif R., Frey, Oliver, Hölscher, Christoph, Iwakura, Yoichiro, Ghilardi, Nico, Ouyang, Wenjun, Kamradt, Thomas, Sabat, Robert, Liesenfeld, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806449/
https://ncbi.nlm.nih.gov/pubmed/19995958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090900
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