The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis

Cul3 (Cullin3)-based E3 ubiquitin ligases recently emerged as critical regulators of mitosis. In this study, we identify two mammalian BTB (Bric-a-brac–Tramtrack–Broad complex)-Kelch proteins, KLHL21 and KLHL22, that interact with Cul3 and are required for efficient chromosome alignment. Interesting...

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Autors principals: Maerki, Sarah, Olma, Michael H., Staubli, Titu, Steigemann, Patrick, Gerlich, Daniel W., Quadroni, Manfredo, Sumara, Izabela, Peter, Matthias
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2009
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806313/
https://ncbi.nlm.nih.gov/pubmed/19995937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200906117
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