Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-κB recruitment to cytokine gene promoters

We previously showed that exposure to febrile-range temperatures (FRT, 39.5–40°C) reduces LPS-induced TNF-α expression, in part through the direct interaction of heat shock factor-1 (HSF1) with the TNF-α gene promoter. However, it is not known whether exposure to FRT also modifies more proximal LPS-...

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Hlavní autoři: Cooper, Zachary A., Ghosh, Arundhati, Gupta, Aditi, Maity, Tapan, Benjamin, Ivor J., Vogel, Stefanie N., Hasday, Jeffrey D., Singh, Ishwar S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2010
Témata:
Receptors and Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806152/
https://ncbi.nlm.nih.gov/pubmed/19846753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00346.2009
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