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Febrile range temperature represses TNF-α gene expression in LPS-stimulated macrophages by selectively blocking recruitment of Sp1 to the TNF-α promoter
We have previously shown that exposure to febrile-range temperature (FRT, 39.5°C) reduces LPS-induced TNF-α transcription in mouse macrophages through at least two mechanisms: (1) by directly recruiting heat shock factor-1 (HSF-1) to a heat shock response element present in the TNF-α 5′-UTR and (2)...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Springer Netherlands
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3006616/ https://ncbi.nlm.nih.gov/pubmed/20221720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-010-0179-9 |
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