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An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals

The sequence of heterocyclic bases on the interior of the DNA double helix constitutes the genetic code that drives the operation of all living organisms. With this said, it is not surprising that chemical modification of cellular DNA can have profound biological consequences. Therefore, the organic...

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Bibliographic Details
Main Author: Gates, Kent S.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806061/
https://ncbi.nlm.nih.gov/pubmed/19757819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900242k
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