Telomere length regulates ISG15 expression in human cells

Endogenous genes regulated by telomere length have not previously been identified in human cells. Here we show that telomere length regulates the expression of interferon stimulated gene 15 (ISG15, 1p36.33). ISG15 expression (RNA and protein) increases in human cells with short telomeres, and decrea...

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Bibliografiske detaljer
Main Authors: Lou, Zhenjun, Wei, Jun, Riethman, Harold, Baur, Joseph A., Voglauer, Regina, Shay, Jerry W., Wright, Woodring E.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2009
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Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806043/
https://ncbi.nlm.nih.gov/pubmed/20157543
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