A purine scaffold Hsp90 inhibitor destabilizes Bcl6 and has specific anti-tumor activity in Bcl6 dependent B-cell lymphomas

We report that Heat shock protein 90 (Hsp90) inhibitors selectively kill Diffuse Large B-cell Lymphomas (DLBCL) that are biologically dependent on the Bcl6 transcriptional repressor. Endogenous Hsp90 was found to interact with Bcl6 in DLBCL cells and could stabilize both Bcl6 mRNA and protein. Hsp90...

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Huvudupphovsmän: Cerchietti, Leandro C, Lopes, Eloisi C, Yang, Shao Ning, Hatzi, Katerina, Bunting, Karen, Tsikitas, Lucas, Mallik, Alka, Robles, Ana I, Walling, Jennifer, Varticovski, Lyuba, Shaknovich, Rita, Bhalla, Kapil, Chiosis, Gabriela, Melnick, Ari M
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805915/
https://ncbi.nlm.nih.gov/pubmed/19966776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2059
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