Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype

BACKGROUND: Tumours contain hypoxic regions that select for an aggressive cell phenotype; tumour hypoxia induces metastasis-associated genes. Treatment refractory patients with metastatic cancer show increased numbers of circulating tumour cells (CTCs), which are also associated with disease progres...

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Detalhes bibliográficos
Main Authors: Ameri, K, Luong, R, Zhang, H, Powell, A A, Montgomery, K D, Espinosa, I, Bouley, D M, Harris, A L, Jeffrey, S S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805847/
https://ncbi.nlm.nih.gov/pubmed/20051957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605491
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