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Positional dependence of transcriptional inhibition by DNA torsional stress in yeast chromosomes

How DNA helical tension is constrained along the linear chromosomes of eukaryotic cells is poorly understood. In this study, we induced the accumulation of DNA (+) helical tension in Saccharomyces cerevisiae cells and examined how DNA transcription was affected along yeast chromosomes. The results r...

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Detalhes bibliográficos
Main Authors: Joshi, Ricky S, Piña, Benjamin, Roca, Joaquim
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805846/
https://ncbi.nlm.nih.gov/pubmed/20057354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.391
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