Probing the Catalytic Potential of the Hamster Arylamine N-Acetyltransferase 2 Catalytic Triad by Site-directed Mutagenesis of the Proximal Conserved Residue, Tyrosine 190

Arylamine N-acetyltransferases (NATs) play an important role in both detoxification of arylamine and hydrazine drugs and activation of arylamine carcinogens. Since the catalytic triad, Cys-His-Asp, of mammalian NATs has been shown to be essential for maintaining protein stability, rendering it impos...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Zhou, Xin, Zhang, Naixia, Liu, Li, Walters, Kylie J., Hanna, Patrick E., Wagner, Carston R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805756/
https://ncbi.nlm.nih.gov/pubmed/19860825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07389.x
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares