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Insights into how protein dynamics affects arylamine N-acetyltransferase catalysis
Arylamine N-acetyltransferases (NATs) detoxify arylamines and hydrazine xenobiotics by catalyzing their N-acetylation, which prevents their bioactivation. Here, we reveal how structural dynamics impact NAT protein function. Our data suggest that there are multiple conformations in the catalytic cavi...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2748875/ https://ncbi.nlm.nih.gov/pubmed/19463782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.05.065 |
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