PKC-permitted elevation of sarcolemmal K(ATP) concentration may explain female-specific resistance to myocardial infarction

The female myocardium, relative to that of the male, exhibits sustained resistance to ischaemic tissue injury, a phenomenon termed sex-specific cardioprotection (SSC). SSC is dependent upon the sarcolemmal K(ATP) channel (sarcK(ATP)), and protein kinase C (PKC). Here we investigate whether PKC-media...

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Main Authors: Edwards, Andrew G, Rees, Meredith L, Gioscia, Rachel A, Zachman, Derek K, Lynch, Joshua M, Browder, Jason C, Chicco, Adam J, Moore, Russell L
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2009
Assuntos:
Cardiovascular
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805381/
https://ncbi.nlm.nih.gov/pubmed/19805744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.181040
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