Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

Persistence of T cells engineered with chimeric antigen receptors (CARs) has been a major barrier to use of these cells for molecularly targeted adoptive immunotherapy. To address this issue, we created a series of CARs that contain the T cell receptor-ζ (TCR-ζ) signal transduction domain with the C...

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Autors principals: Milone, Michael C., Fish, Jonathan D., Carpenito, Carmine, Carroll, Richard G., Binder, Gwendolyn K., Teachey, David, Samanta, Minu, Lakhal, Mehdi, Gloss, Brian, Danet-Desnoyers, Gwenn, Campana, Dario, Riley, James L., Grupp, Stephan A., June, Carl H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805264/
https://ncbi.nlm.nih.gov/pubmed/19384291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.83
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