Thrombin Induces Tumor Invasion through the Induction and Association of Matrix Metalloproteinase-9 and β1-Integrin on the Cell Surface

The procoagulatory serine protease, thrombin, is known to induce invasion and metastasis in various cancers, but the mechanisms by which it promotes tumorigenesis are poorly understood. Because the 92-kDa gelatinase (MMP-9) is a known mediator of tumor cell invasion, we sought to determine whether a...

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Main Authors: Radjabi, A. Reza, Sawada, Kenjiro, Jagadeeswaran, Sujatha, Eichbichler, Alfred, Kenny, Hilary A., Montag, Anthony, Bruno, Katharina, Lengyel, Ernst
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805198/
https://ncbi.nlm.nih.gov/pubmed/18048360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M704855200
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