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Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in post-mitotic cells
In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of these multi-protein transport channels in post-mitotic cells, where the mitotic renewal of pores is absent, is unknown. Here we show that NPCs, unlike other...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2805151/ https://ncbi.nlm.nih.gov/pubmed/19167330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.11.037 |
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