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Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in post-mitotic cells

In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of these multi-protein transport channels in post-mitotic cells, where the mitotic renewal of pores is absent, is unknown. Here we show that NPCs, unlike other...

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Detalhes bibliográficos
Main Authors: D’Angelo, Maximiliano A., Raices, Marcela, Panowski, Siler H., Hetzer, Martin W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805151/
https://ncbi.nlm.nih.gov/pubmed/19167330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.11.037
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