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Nkx2.2-repressor activity is sufficient to specify α-cells and a small number of β-cells in the pancreatic islet
The homeodomain protein Nkx2.2 (Nkx2-2) is a key regulator of pancreatic islet cell specification in mice; Nkx2.2 is essential for the differentiation of all insulin-producing β-cells and of the majority of glucagon-producing α-cells, and, in its absence, these cell types are converted to a ghrelin...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2805074/ https://ncbi.nlm.nih.gov/pubmed/17202186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.02763 |
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