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Nkx2.2 Activates the Ghrelin Promoter in Pancreatic Islet Cells

Nkx2.2 is an essential regulator of pancreatic endocrine differentiation. Nkx2.2-null mice are completely devoid of β-ells and have a large reduction of α- and PP cells. In the place of these islet populations, there is a corresponding increase in the ghrelin-positive ε-cells. Molecular studies have...

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Autores principales: Hill, Jonathon T., Chao, Christina S., Anderson, Keith R., Kaufman, Fernanda, Johnson, Christopher W., Sussel, Lori
Formato: Artigo
Lenguaje:Inglês
Publicado: The Endocrine Society 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817598/
https://ncbi.nlm.nih.gov/pubmed/19965928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0360
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