Altered Gene Expression in Morphologically Normal Epithelial Cells from Heterozygous Carriers of BRCA1 or BRCA2 Mutations

We hypothesized that cells bearing a single inherited “hit” in a tumor suppressor gene express an altered mRNA repertoire that may identify targets for measures that could delay or even prevent progression to carcinoma. We report here on the transcriptomes of primary breast and ovarian epithelial ce...

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Detalhes bibliográficos
Main Authors: Bellacosa, Alfonso, Godwin, Andrew K., Peri, Suraj, Devarajan, Karthik, Caretti, Elena, Vanderveer, Lisa, Bove, Betsy, Slater, Carolyn, Zhou, Yan, Daly, Mary, Howard, Sharon, Campbell, Kerry, Nicolas, Emmanuelle, Yeung, Anthony T., Clapper, Margie L., Crowell, James A., Lynch, Henry T., Ross, Eric, Kopelovich, Levy, Knudson, Alfred G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804937/
https://ncbi.nlm.nih.gov/pubmed/20051372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-09-0078
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