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Recombinant protein expression by targeting pre-selected chromosomal loci

BACKGROUND: Recombinant protein expression in mammalian cells is mostly achieved by stable integration of transgenes into the chromosomal DNA of established cell lines. The chromosomal surroundings have strong influences on the expression of transgenes. The exploitation of defined loci by targeting...

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Detalhes bibliográficos
Main Authors: Nehlsen, Kristina, Schucht, Roland, da Gama-Norton, Leonor, Krömer, Wolfgang, Baer, Alexandra, Cayli, Aziz, Hauser, Hansjörg, Wirth, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804664/
https://ncbi.nlm.nih.gov/pubmed/20003421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-9-100
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