Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

A substantially enriched preparation of Alzheimer paired helical filaments (PHFs) has been used as a starting point for biochemical studies. Pronase treatment, which strips off adhering proteins, leaves a resistant core that is structurally intact. This has been used to raise a monoclonal antibody t...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Wischik, C M, Novak, M, Thøgersen, H C, Edwards, P C, Runswick, M J, Jakes, R, Walker, J E, Milstein, C, Roth, M, Klug, A
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1988
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280459/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3132715/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.12.4506
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