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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

A substantially enriched preparation of Alzheimer paired helical filaments (PHFs) has been used as a starting point for biochemical studies. Pronase treatment, which strips off adhering proteins, leaves a resistant core that is structurally intact. This has been used to raise a monoclonal antibody t...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Wischik, C M, Novak, M, Thøgersen, H C, Edwards, P C, Runswick, M J, Jakes, R, Walker, J E, Milstein, C, Roth, M, Klug, A
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1988
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280459/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3132715/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.12.4506
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