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Vascular endothelial specific dimethylarginine dimethylaminohydrolase-1 deficient mice reveal vascular endothelium plays an important role in removing asymmetric dimethylarginine
BACKGROUND: Asymmetric methylarginines inhibit nitric oxide (NO) synthase (NOS) activity and thereby decrease NO production. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) degrades asymmetric methylarginines. We previously demonstrated that in the heart DDAH1 is predominantly expressed in vascula...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804399/ https://ncbi.nlm.nih.gov/pubmed/19917889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.819912 |
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