Vascular endothelial specific dimethylarginine dimethylaminohydrolase-1 deficient mice reveal vascular endothelium plays an important role in removing asymmetric dimethylarginine

BACKGROUND: Asymmetric methylarginines inhibit nitric oxide (NO) synthase (NOS) activity and thereby decrease NO production. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) degrades asymmetric methylarginines. We previously demonstrated that in the heart DDAH1 is predominantly expressed in vascula...

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Hauptverfasser: Hu, Xinli, Xu, Xin, Zhu, Guangshuo, Atzler, Doro, Kimoto, Masumi, Chen, Ju, Schwedhelm, Edzard, Lüneburg, Nicole, Böger, Rainer H., Zhang, Ping, Chen, Yingjie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804399/
https://ncbi.nlm.nih.gov/pubmed/19917889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.819912
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