Dimethylarginine Dimethylaminohydrolase-1 Transgenic Mice Are Not Protected from Ischemic Stroke

BACKGROUND: Methylated arginines are endogenous analogues of L-arginine, the substrate for nitric oxide (NO) synthase. Asymmetric dimethylarginine (ADMA) interferes with NO formation, causing endothelial dysfunction. ADMA is a predictor of cardiovascular events and mortality in humans. It is elimina...

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Main Authors: Leypoldt, Frank, Choe, Chi-Un, Gelderblom, Mathias, von Leitner, Eike-Christin, Atzler, Dorothee, Schwedhelm, Edzard, Gerloff, Christian, Sydow, Karsten, Böger, Rainer H., Magnus, Tim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753663/
https://ncbi.nlm.nih.gov/pubmed/19809508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007337
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