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Dimethylarginine Dimethylaminohydrolase1 Is an Organ-Specific Mediator of End Organ Damage in a Murine Model of Hypertension

BACKGROUND: The endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) is an independent predictor of cardiovascular and overall mortality. Moreover, elevated ADMA plasma concentrations are associated with the extent of hypertension. However, data from small-sized clinical tri...

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Detalhes bibliográficos
Main Authors: Sydow, Karsten, Schmitz, Christine, von Leitner, Eike-Christin, von Leitner, Robin, Klinke, Anna, Atzler, Dorothee, Krebs, Christian, Wieboldt, Hartwig, Ehmke, Heimo, Schwedhelm, Edzard, Meinertz, Thomas, Blankenberg, Stefan, Böger, Rainer H., Magnus, Tim, Baldus, Stephan, Wenzel, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482201/
https://ncbi.nlm.nih.gov/pubmed/23110194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048150
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