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Integrin αIIbβ3 Activation in Chinese Hamster Ovary Cells and Platelets Increases Clustering Rather than Affinity

Integrin αIIbβ3 affinity regulation by talin binding to the cytoplasmic tail of β3 is a generally accepted model for explaining activation of this integrin in Chinese hamster ovary cells and human platelets. Most of the evidence for this model comes from the use of multivalent ligands. This raises t...

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Sonraí Bibleagrafaíochta
Príomhúdar: Bunch, Thomas A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804342/
https://ncbi.nlm.nih.gov/pubmed/19917607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057349
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