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Production of oxidative DNA damage during the metabolic activation of benzo[a]pyrene in human mammary epithelial cells correlates with cell killing.

We have studied the generation of reactive oxygen species during the metabolism of a carcinogen, benzo[a]pyrene, by human mammary epithelial cells. We have quantitated the production of one type of oxidative DNA damage, thymine glycols, by using a monoclonal antibody specific to this base modificati...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Leadon, S A, Stampfer, M R, Bartley, J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1988
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC280429/
https://ncbi.nlm.nih.gov/pubmed/3380798
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