Benzo[a]pyrene perturbs mitochondrial and amino acid metabolism in lung epithelial cells and has similar correlations with metabolic changes in human serum

OBJECTIVE: A study was conducted to identify metabolic-related effects of benzo[a]pyrene (BaP) on human lung epithelial cells and validate these findings using human sera. METHODS: Human lung epithelial cells were treated with BaP, and extracts were analyzed with a global metabolome-wide association...

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Udgivet i:J Occup Environ Med
Main Authors: Smith, Matthew Ryan, Walker, Douglas I., Uppal, Karan, Utell, Mark J., Hopke, Philip K., Mallon, Timothy M., Krahl, Pamela L., Rohrbeck, Patricia, Go, Young-Mi, Jones, Dean P.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897313/
https://ncbi.nlm.nih.gov/pubmed/31800453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JOM.0000000000001687
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