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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
Dihydropteroate synthase (DHPS) is a key enzyme in bacterial folate synthesis and the target of the sulfonamide class of antibacterials. Resistance and toxicities associated with sulfonamides have led to a decrease in their clinical use. Compounds that bind to the pterin binding site of DHPS, as opp...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804029/ https://ncbi.nlm.nih.gov/pubmed/19899766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900861d |
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