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Genetic Alterations in K-ras and p53 Cancer Genes in Lung Neoplasms From B6C3F1 Mice Exposed to Cumene

The incidences of alveolar/bronchiolar adenomas and carcinomas in cumene-treated B6C3F1 mice were significantly greater than those of the controls. We evaluated these lung neoplasms for point mutations in the K-ras and p53 genes that are often mutated in humans. K-ras and p53 mutations were detected...

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Detalhes bibliográficos
Main Authors: Hong, Hue-Hua L., Ton, Thai-Vu. T., Kim, Yongbaek, Wakamatsu, Nobuko, Clayton, Natasha P., Chan, Po-Chuen, Sills, Robert C., Lahousse, Stephanie A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803761/
https://ncbi.nlm.nih.gov/pubmed/18648094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623308320280
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