Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma

Tumor–bone marrow microenvironment interactions in multiple myeloma (MM) are documented to play crucial roles in plasma-cell growth/survival. In vitro coculture of MM cells with osteoclasts supported cell survival and significantly down-regulated JUN expression. JUN expression in myeloma cells from...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Lijuan, Wang, Siqing, Zhou, Yiming, Wu, Xiaosong, Entin, Igor, Epstein, Joshua, Yaccoby, Shmuel, Xiong, Wei, Barlogie, Bart, Shaughnessy, John D., Zhan, Fenghuang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2010
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803692/
https://ncbi.nlm.nih.gov/pubmed/19837979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-210526
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