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Gene disruption study reveals a non-redundant role for TRIM21/Ro52 in NF-κB-dependent cytokine expression in fibroblasts
The tripartite motif (TRIM) family member, TRIM21, is an E3 ubiquitin ligase for IRF3 and IRF8 that functions in both innate and acquired immunity. It is also an autoantigen known as Ro52/SS-A. The function of TRIM21 in vivo, however, has remained elusive. We generated Trim21(−/−) mice with the Trim...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2803686/ https://ncbi.nlm.nih.gov/pubmed/19494276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804121 |
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