Neurotransmitter release is blocked intracellularly by botulinum neurotoxin, and this requires uptake of both toxin polypeptides by a process mediated by the larger chain.

Botulinum neurotoxins (types A and B), which are microbial proteins consisting of two disulfide-linked chains, inhibit specifically and with high potency the release of acetylcholine from peripheral nerve terminals. As a prerequisite for a long-term development of effective treatments for botulism,...

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Bibliographic Details
Main Authors:	Poulain, B, Tauc, L, Maisey, E A, Wadsworth, J D, Mohan, P M, Dolly, J O
Format:	Artigo
Language:	Inglês
Published:	1988
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC280368/ https://ncbi.nlm.nih.gov/pubmed/2897693
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Neurotransmitter release is blocked intracellularly by botulinum neurotoxin, and this requires uptake of both toxin polypeptides by a process mediated by the larger chain.

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