Neurotransmitter release is blocked intracellularly by botulinum neurotoxin, and this requires uptake of both toxin polypeptides by a process mediated by the larger chain.

Botulinum neurotoxins (types A and B), which are microbial proteins consisting of two disulfide-linked chains, inhibit specifically and with high potency the release of acetylcholine from peripheral nerve terminals. As a prerequisite for a long-term development of effective treatments for botulism,...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Poulain, B, Tauc, L, Maisey, E A, Wadsworth, J D, Mohan, P M, Dolly, J O
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280368/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2897693/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.11.4090
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