PDEs1-5 activity and expression in tissues of cirrhotic rats reveal a role for aortic PDE3 in NO desensitization

Liver cirrhosis is associated with increased nitric oxide (NO) production in the vasculature. We have previously demonstrated that aorta from rats with liver cirrhosis have a reduced relaxant response to NO donors that is corrected by DMPPO, a PDE5-specific inhibitor. Vasodilator responses to DMPPO...

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Detalhes bibliográficos
Main Authors: Tahseldar-Roumieh, Rima, Keravis, Thérèse, Maarouf, Suha, Justiniano, Hélène, Sabra, Ramzi, Lugnier, Claire
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803251/
https://ncbi.nlm.nih.gov/pubmed/19758418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2613.2009.00678.x
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