Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4 (PDE4) Inhibitor

Systemic lupus erythematosus is a polymorphic and multigenic inflammatory autoimmune disease. Cyclic AMP (cAMP) modulates inflammation and the inhibition of cyclic nucleotide phosphodiesterase type 4 (PDE4), which specifically hydrolyzes cAMP, inhibits TNFα secretion. This study was aimed at investi...

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Detalhes bibliográficos
Main Authors: Keravis, Thérèse, Monneaux, Fanny, Yougbaré, Issaka, Gazi, Lucien, Bourguignon, Jean-Jacques, Muller, Sylviane, Lugnier, Claire
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256138/
https://ncbi.nlm.nih.gov/pubmed/22247763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028899
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