PDEs1-5 activity and expression in tissues of cirrhotic rats reveal a role for aortic PDE3 in NO desensitization

Liver cirrhosis is associated with increased nitric oxide (NO) production in the vasculature. We have previously demonstrated that aorta from rats with liver cirrhosis have a reduced relaxant response to NO donors that is corrected by DMPPO, a PDE5-specific inhibitor. Vasodilator responses to DMPPO...

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Bibliographische Detailangaben
Hauptverfasser: Tahseldar-Roumieh, Rima, Keravis, Thérèse, Maarouf, Suha, Justiniano, Hélène, Sabra, Ramzi, Lugnier, Claire
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2009
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803251/
https://ncbi.nlm.nih.gov/pubmed/19758418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2613.2009.00678.x
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