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The cationic cluster of group IVA phospholipase A(2) (Lys(488)/Lys(541)/Lys(543)/Lys(544)) is involved in translocation of the enzyme to phagosomes in human macrophages

Group IVA cytosolic phospholipase A(2)α (cPLA(2)α) plays a role in the microbicidal machinery of immune cells by translocating to phagosomes to initiate the production of antimicrobial eicosanoids. In this work, we have studied the involvement of the cationic cluster of cPLA(2)α (Lys(488)/Lys(541)/L...

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Détails bibliographiques
Auteurs principaux: Casas, Javier, Valdearcos, Martín, Pindado, José, Balsinde, Jesús, Balboa, María A.
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803241/
https://ncbi.nlm.nih.gov/pubmed/19717620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M001461
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