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The cationic cluster of group IVA phospholipase A(2) (Lys(488)/Lys(541)/Lys(543)/Lys(544)) is involved in translocation of the enzyme to phagosomes in human macrophages
Group IVA cytosolic phospholipase A(2)α (cPLA(2)α) plays a role in the microbicidal machinery of immune cells by translocating to phagosomes to initiate the production of antimicrobial eicosanoids. In this work, we have studied the involvement of the cationic cluster of cPLA(2)α (Lys(488)/Lys(541)/L...
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Auteurs principaux: | , , , , |
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Format: | Artigo |
Langue: | Inglês |
Publié: |
The American Society for Biochemistry and Molecular Biology
2010
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2803241/ https://ncbi.nlm.nih.gov/pubmed/19717620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M001461 |
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