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Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor
The LDL receptor (LDL-R) mediates cholesterol metabolism in humans by binding and internalizing cholesterol transported by LDL. Several different molecular mechanisms have been proposed for the binding of LDL to LDL-R at neutral plasma pH and for its release at acidic endosomal pH. The crystal struc...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2803231/ https://ncbi.nlm.nih.gov/pubmed/19674976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M000422 |
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