Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation

Eitemau Tebyg

• Increased numbers of pre-existing memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells()
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• TLR4 ligands LPS and MPLA differentially regulate effector and memory CD8(+) T cell differentiation
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• Defect of CD8(+) Memory T Cells Developed in Absence of IL-12 Priming for Secondary Expansion
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