Extension of Drosophila melanogaster lifespan with a GPCR peptide inhibitor

G protein-coupled receptors (GPCRs) mediate signaling from extracellular ligands to intracellular signal transduction proteins1. Methuselah (Mth) is a class B (secretin-like) GPCR, a family typified by their large, ligand-binding, N-terminal extracellular domains2. Down-regulation of mth increases t...

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Main Authors: Ja, William W., West, Anthony P., Delker, Silvia L., Bjorkman, Pamela J., Benzer, Seymour, Roberts, Richard W.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803097/
https://ncbi.nlm.nih.gov/pubmed/17546039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2007.2
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